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Safety and tolerability of interferon beta-1b in pediatric multiple sclerosis: A Multicenter Study.

Journal: 
Neurology 2006;66:472-6

Background: Immunomodulatory therapies are widely used in adults with multiple sclerosis (MS) and safety and tolerability is well-established. Although at least 5% of all patients with MS experience the clinical onset of their disease prior to age 18 years, the available literature on safety and tolerability of immunomodulatory therapies for pediatric-onset MS is limited.

Methods: The authors retrospectively reviewed safety and tolerability of interferon beta-1b (IFNβ-1b) in a cohort of 43 children and adolescents treated for a mean of 29.2 months (SD 22.3 months).

Results: Mean age at start of IFNβ-1b treatment was 13 years. Eight children were ≤10 years. Most common adverse events included flu-like syndrome (35%), abnormal liver function test (26%), and injection site reaction (21%). No serious or unexpected adverse events were reported.

Conclusions: Although data on long-term effects on the maturing organ systems are lacking, the safety profile supports the safety and tolerability of interferon beta-1b (IFNβ-1b) in children with multiple sclerosis and related diseases. All patients treated with IFNβ-1b should undergo regular monitoring of liver function.